Daclatasvir Dihydrochlorid
Beschreiwung
Daclatasvir Dihydrochlorid (BMS-790052 Dihydrochlorid) ass eng mächteg a mëndlech aktivHCV NS5A Proteininhibitor matEC50s Gamme vun 9-146 PM firMultiple HCV Replikon Genotypen. Daclatasvir Dihydrochlorid ass och engorganesch Anion transportéierend Polypeptid 1B (OATP1B)anOATP1B3inhibitor matIC50s vun 1,5 µM respektiv 3,27 µM.
IC50& Zil
EC50: 50 pM (HCV Replicon Genotyp 1a), 9 pM (HCV Replicon Genotyp 1b), 71 pM (HCV Replicon Genotyp 2a), 146 pM (HCV Replicon Genotyp 3a), 12 pM (HCV Replicon Genotyp 33 pM) HCV Replikon Genotyp 5a)[1]
Kd: 8 nM (NS5A33-202) an 210 nM (NS5A26-202)[2]
IC50: 1,5 µM (OATP1B) an 3,27 µM (OATP1B3)[3]
In Vitro
Daclatasvir (BMS-790052) weist mächteg hemmungsaktiv Aktivitéit géint all getest Genotypen, mat EC50Wäerter vun 9 bis 146 Auer. Daclatasvir hemmt HCV Replikon Genotyp 1a, 1b, 2a, 3a, 4a a 5a mat EC50Wäerter vun 50 pM, 9 pM, 71 pM, 146 pM, 12 pM an 33 pM, respektiv. Daclatasvir ass e mächtege Inhibitor vum JFH-1 Genotyp 2a ustiechend Virus deen an Zellkultur replizéiert (EC)50= 28 Uhr)[1]. Daclatasvir (BMS-790052) bindt enk un NS5A33-202 an NS5A26-202 mat Kds vun 8 nM an 210 nM, respektiv[2].
Stockage
| Pudder | -20°C | 3 Joer |
| 4°C | 2 Joer | |
| Am Léisungsmëttel | -80°C | 6 Méint |
| -20°C | 1 Mount |
Klinesch Prozess
| NCT Zuel | Sponsor | Zoustand | Start Datum | Phase |
| NCT03369327 | Teheran University of Medical Sciences|RojanPharma Pharmaceutical Company | Hepatitis C Virus Infektioun, Äntwert op Therapie vum Mënsch Immunodeficiency Virus | Januar 1, 2017 | Phase 3 |
| NCT03485846 | R-Pharm|Almedis | Chronesch Hepatitis C Genotyp 1b | 27. November 2017 | Phase 2 |
| NCT01016912 | Bristol-Myers Squibb | Hepatitis C Infektioun | Dezember 2009 | Phase 2 |
| NCT01629732 | Bristol-Myers Squibb | Hepatitis C Virus | Mäerz 2013 | Phase 2 |
| NCT01497834 | Bristol-Myers Squibb | Hepatitis C | Januar 2012 | Phase 3 |
| NCT01973049 | Bristol-Myers Squibb | Hepatitis C | Dezember 2013 | Phase 3 |
| NCT00663208 | Bristol-Myers Squibb | Chronesch Hepatitis C | Mee 2008 | Phase 2 |
| NCT02576314 | Humanity and Health Research Centre|Beijing 302 Hospital | Chronesch Hepatitis C Infektioun | Mee 2015 | Phase 3 |
| NCT02756936 | Genuine Research Center, Egypt|Zeta Pharma Pharmaceutical Industries | Gesond | Februar 2016 | Phase 1 |
| NCT02771405 | National Hepatology & Tropical Medicine Research Institute | Kairo Universitéit | Hepatitis C, Chronesch|Hepatocellulär Karzinom | Mäerz 2016 | Phase 3 |
| NCT03706898 | Viriom | HIV-1-Infektioun|Hepatesch Behënnerung | 1. Oktober 2018 | Phase 1 |
| NCT02319031 | Bristol-Myers Squibb | Hepatitis C | Februar 2015 | Phase 3 |
| NCT02124044 | National Institutes of Health Clinical Center (CC)|National Institute of Allergy and Infectious Diseases (NIAID)|Bristol-Myers Squibb | HIV-HCV | Februar 2014 | Phase 2 |
| NCT02551861 | Bristol-Myers Squibb | Hepatitis C | Dezember 2015 | Phase 2 |
| NCT00859053 | Bristol-Myers Squibb | Hepatesch Insuffizienz | März 2009 | Phase 1 |
| NCT01257204 | Bristol-Myers Squibb | Hepatitis C Virus | Dezember 2010 | Phase 2 |
| NCT03063879 | Teheran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Hamadan University of Medical Science | Hepatitis C, Chronesch|chronesch Nierenausfall | Abrëll 1, 2017 | Phase 4 |
| NCT01017575 | Bristol-Myers Squibb | Hepatitis C Infektioun | Dezember 2009 | Phase 2 |
| NCT02865369 | Sang Gyune Kim|Seoul National University Boramae Hospital|Severance Hospital|Inha University Hospital|Korea University|Gachon University Gil Medical Center|Hanyang University Seoul Hospital|Ewha Womans University Mokdong Hospital|Bristol-Myers Squibb|Soonchunhyang University Hospital | Chronesch Hepatitis C | September 2016 |
|
| NCT04070235 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Hepatitis C, chronesch | 29. Mäerz 2019 | Phase 2|Phase 3 |
| NCT03487848 | Bristol-Myers Squibb | Hepatitis C | Chronesch Hepatitis | 18. Mee 2018 | Phase 2 |
| NCT00904059 | Bristol-Myers Squibb | Hepatitis C | Mee 2009 | Phase 1 |
| NCT02107365 | Franséisch Institut national fir Gesondheet a Medizinesch Fuerschung - Franséisch National Agentur fir Fuerschung iwwer AIDS a Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotyp 4 Infektioun | November 2013 | Phase 2 |
| NCT02397395 | Janssen R&D Irland | Nierenausfall|Endstadium Nier Krankheet | Mee 2015 | Phase 2 |
| NCT03169348 | Assiut Universitéit | Hepatitis C | November 1, 2017 | Net applicabel |
| NCT02323594 | Bristol-Myers Squibb | Hepatitis C Infektioun | Dezember 2014 | Phase 1 |
| NCT03537196 | Franséisch Institut national fir Gesondheet a Medizinesch Fuerschung - Agence national fir Fuerschung iwwer AIDS a Viral Hepatitis (Inserm-ANRS) | Hepatitis C|Droge benotzt|Viral Hepatitis C | November 13, 2018 | Phase 4 |
| NCT02103569 | Bristol-Myers Squibb | Hepatitis C | Abrëll 2014 | Phase 1 |
| NCT02772744 | Zagazig Universitéit|Kairo Universitéit | Hepatitis C | November 1, 2017 |
|
| NCT01718158 | Bristol-Myers Squibb | Hepatitis C | Januar 2013 | Phase 3 |
| NCT02496078 | Bristol-Myers Squibb | Hepatitis C | August 2015 | Phase 3 |
| NCT01425970 | Bristol-Myers Squibb | Hepatitis C | Mee 2012 | Phase 2 |
| NCT01471574 | Bristol-Myers Squibb | Hepatitis C, Genotyp 1 | Dezember 2011 | Phase 3 |
| NCT01573351 | Bristol-Myers Squibb | Hepatitis C Virus | Mee 2012 | Phase 3 |
| NCT01938625 | Janssen R&D Irland | Hepatitis C, chronesch | 12. Dezember 2013 | Phase 2 |
| NCT01492426 | Bristol-Myers Squibb | Hepatitis C | Januar 2012 | Phase 3 |
| NCT03480932 | Johns Hopkins Bloomberg School of Public Health|National Institute on Drug Abuse (NIDA)|YR Gaitonde Center for AIDS Research and Education | Hepatitis C, chronesch | 2. Februar 2018 | Phase 2|Phase 3 |
| NCT03163849 | Assiut Universitéit | Chronesch Hepatitis c | September 1, 2019 | Phase 3 |
| NCT01581203 | Bristol-Myers Squibb | Hepatitis C Virus | Mee 2012 | Phase 3 |
| NCT01492504 | Bristol-Myers Squibb | Hepatitis C | 7. Februar 2012 |
|
| NCT03686722 | Mohamed Raslan|Ain Shams University|Drug Research Center, Kairo, Ägypten | Diabetis mellitus, Typ 2 | Hepatitis C | Medikamenter Interaktiounen | September 9, 2017 | Phase 1 |
| NCT02262728 | Janssen Research & Development, LLC | Hepatitis C, chronesch | 30. September 2014 | Phase 2 |
| NCT02349048 | Janssen Research & Development, LLC | Hepatitis C Virus | Januar 2015 | Phase 2 |
| NCT03882307 | Assiut Universitéit | Hepatitis C, chronesch | Mee 2020 | Fréier Phase 1 |
| NCT02758509 | Parc de Salut Mar | Chronesch Hepatitis C | Zirrhose | 1. Januar 2010 |
|
| NCT01795911 | Bristol-Myers Squibb | Hepatitis C | Mäerz 2013 | Phase 2 |
| NCT03549832 | Assiut Universitéit|Sohag Universitéit|South Valley Universitéit | HCV Coinfection | Januar 1, 2018 | Net applicabel |
| NCT02161939 | Bristol-Myers Squibb | Chronesch Hepatitis C |
| |
| NCT01309932 | Bristol-Myers Squibb | Hepatitis C | Mäerz 2011 | Phase 2 |
| NCT01995266 | Bristol-Myers Squibb | Hepatitis C | 28. Februar 2014 | Phase 3 |
| NCT02640157 | Abb Vie | Chronesch Hepatitis C|Hepatitis C Virus|Genotyp 3 Hepatitis C Virus | Dezember 2015 | Phase 3 |
| NCT02032875 | Bristol-Myers Squibb | Hepatitis C | Mäerz 2014 | Phase 3 |
| NCT02624063 | Bundesuniversitéit vu São Paulo | Hepatitis C, chronesch | Dezember 2015 | Phase 4 |
| NCT00546715 | Bristol-Myers Squibb | Chronesch Hepatitis C | November 2007 | Phase 1|Phase 2 |
| NCT01718145 | Bristol-Myers Squibb | Hepatitis C Virus Infektioun | November 2012 | Phase 3 |
| NCT01616524 | Bristol-Myers Squibb | Hepatitis C Virus (HCV) | Juli 2012 | Phase 3 |
| NCT02032901 | Bristol-Myers Squibb | Hepatitis C | Januar 2014 | Phase 3 |
| NCT03540212 | Ain Shams Universitéit | Chronesch HCV Infektioun | Dezember 10, 2017 | Phase 2|Phase 3 |
| NCT02097966 | Bristol-Myers Squibb | Chronesch Hepatitis C |
| |
| NCT02596880 | Teheran University of Medical Sciences | Hepatitis C | Zirrhose | September 2015 | Phase 3 |
| NCT04019717 | D'Geschicht vun Atea Pharmaceuticals, Inc. | Hepatitis C|Hepatitis C, Chronesch|Chronesch Hepatitis C|Hepatitis C Virusinfektioun|HCV Infektioun | Juni 20, 2019 | Phase 2 |
| NCT02992457 | Tanta Universitéit | Hepatitis C | Januar 2015 | Phase 4 |
| NCT03547895 | Zagazig Universitéit | Dekompenséiert Zirrhosis | 1. Juni 2015 | Net applicabel |
| NCT03004625 | Kaohsiung Medical University Chung-Ho Memorial Hospital|Chang Gung Memorial Hospital|National Taiwan University Hospital|Taipei Veterans General Hospital, Taiwan|China Medical University Hospital|National Cheng-Kung University Hospital | Hepatitis C | November 2016 | Phase 3 |
| NCT01051414 | Bristol-Myers Squibb | Hepatitis C Infektioun | Abrëll 2010 | Phase 2 |
| NCT02309450 | Franséisch Institut national fir Gesondheet a Medizinesch Fuerschung - Franséisch National Agentur fir Fuerschung iwwer AIDS a Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | Hepatitis C Virus Genotyp 4 Infektioun | Dezember 2014 | Phase 2 |
| NCT01628692 | Bristol-Myers Squibb|Janssen Research & Development, LLC | Hepatitis C Virus | Juli 2012 | Phase 2 |
| NCT03186313 | Egyptian Liver Hospital|Wadi El Nil Hospital | Hepatitis C | September 2016 | Phase 3 |
| NCT03063723 | Drëtt verbonne Spidol, Sun Yat-Sen Universitéit | Chronesch Hepatitis C (Stéierungen) | 1. Januar 2016 |
|
| NCT00983957 | Bristol-Myers Squibb | Chronesch Hepatitis C | Oktober 2009 | Phase 1 |
| NCT01725542 | Franséisch Institut national fir Gesondheet a Medizinesch Fuerschung - Franséisch National Agentur fir Fuerschung iwwer AIDS a Viral Hepatitis (Inserm-ANRS)|Bristol-Myers Squibb | HCV-HIV Co-Infektioun | Dezember 2012 | Phase 2 |
| NCT02282709 | Fondatioun fir Liewer Fuerschung | Chronesch Hepatitis C | Februar 2014 | Phase 3 |
| NCT02032888 | Bristol-Myers Squibb | Hepatitis C | Februar 2014 | Phase 3 |
| NCT03247296 | MTI Universitéit | Hepatitis C | 28. Februar 2017 |
|
| NCT01389323 | Bristol-Myers Squibb | Hepatitis C | September 2011 | Phase 3 |
| NCT02556086 | Bristol-Myers Squibb | Hepatitis C | Dezember 2015 | Phase 2 |
| NCT01741545 | Bristol-Myers Squibb | Hepatitis C Virus | 31. Mäerz 2013 | Phase 3 |
| NCT01866930 | Bristol-Myers Squibb | Chronesch Hepatitis C Infektioun | 11. Juli 2013 | Phase 3 |
| NCT02268864 | Janssen-Cilag International NV | Hepatitis C, chronesch | Januar 2015 | Phase 2 |
| NCT01797848 | Bristol-Myers Squibb | Hepatitis C | Juni 2014 | Phase 3 |
| NCT03166280 | Eman Sayed Hassan Abd Allah|Assiut Universitéit | Hepatitis C | Juni 2017 |
|
| NCT02159352 | Bristol-Myers Squibb | Hepatitis C | Juni 2014 | Phase 1 |
| NCT01125189 | Bristol-Myers Squibb | Hepatitis C Virus | Juli 2010 | Phase 2 |
| NCT03748745 | Nanjing Sanhome Pharmaceutical, Co., Ltd. | Drogen Interaktiounen | November 19, 2018 | Phase 1 |
| NCT01012895 | Bristol-Myers Squibb | Chronesch Hepatitis C | Dezember 2009 | Phase 2 |
| NCT02565888 | Radboud Universitéit | Hepatitis C|HIV | November 2015 | Phase 1 |
| NCT02555943 | Humanity and Health Research Center|Beijing 302 Hospital|Nanfang Hospital of Southern Medical University | Chronesch Hepatitis C Infektioun|HBV Coinfection|Hepatitis B Reaktivéierung | Februar 2015 | Phase 2|Phase 3 |
| NCT02304159 | Tarek I. Hassanein, MD, FACP, FAG, AGAF|Southern California Research Center | Hepatitis C | Zirrhose | Januar 2015 | Phase 4 |
| NCT02580474 | Myeong Jun Song|Bristol-Myers Squibb|Soonchunhyang University Hospital|Dankook University|Chungnam National University Hospital|Konyang University Hospital|Eulji University Hospital|Saint Vincent's Hospital, Korea|Konkuk University Hospital|Cheongju St. Mary's Hospital, Cheongju , Korea|Severance Hospital|Korea University Guro Hospital|Eulji General Hospital|The Catholic University of Korea | Hepatitis C | Februar 2016 | Phase 4 |
| NCT02104843 | Bristol-Myers Squibb | Hepatitis C | Abrëll 2014 | Phase 1 |
| NCT01428063 | Bristol-Myers Squibb | Hepatitis C Virus Infektioun | September 2011 | Phase 2 |
| NCT02123654 | Bristol-Myers Squibb | Hepatitis C Virus Infektioun | Abrëll 2014 | Phase 3 |
| NCT02565862 | Radboud Universitéit | Hepatitis C | Diabetis mellitus | Insulinresistenz | Januar 2016 | Phase 1 |
| NCT04211844 | Ain Shams Universitéit | Chronesch Hepatitis C | 1. Oktober 2019 |
|
| NCT00874770 | Bristol-Myers Squibb | Hepatitis C Infektioun | Juni 2009 | Phase 2 |
| NCT03883698 | Sanjay Gandhi Postgraduate Institut fir Medizinesch Wëssenschaften | Nierenausfall, Chronesch | Hepatitis C | Mäerz 15, 2019 | Phase 3 |
| NCT01448044 | Bristol-Myers Squibb | Hepatitis C | Dezember 2011 | Phase 3 |
| NCT01359644 | Bristol-Myers Squibb|Pharmasset | Chronesch Hepatitis C | Juni 2011 | Phase 2 |
| NCT01842451 | D'Kapitaliséierung vu Vertex Pharmaceuticals Incorporated ass haut | Chronesch Hepatitis C|CHC|HCV|Hepatitis C | Juni 2013 | Phase 2 |
| NCT02762448 | Tainan Municipal Spidol | Hepatitis c | Juli 2016 |
|
| NCT02473211 | Humanity and Health Research Centre|Beijing 302 Hospital | Chronesch Hepatitis C Infektioun | Januar 2015 | Phase 2|Phase 3 |
| NCT01455090 | Bristol-Myers Squibb | Chronesch Hepatitis C | 30. November 2011 | Phase 2 |
| NCT03490097 | Ain Shams Universitéit | Chronesch Hepatitis c | Metabolescht Syndrom | Dezember 1, 2017 | Phase 2|Phase 3 |
| NCT01170962 | Bristol-Myers Squibb | Hepatitis C Virus | August 2010 | Phase 2 |
| NCT02333292 | Valme University Hospital|Spidol del SAS de Jerez|Spidol General Universitario Elche|Spidol La Línea de la Concepción|Complexo Hospitalario Universitario de A Coruña|Spidol de Figueres|Spidol Universitario Puerto Real|Spidol Universitario Virgen de la Victoria|Spidol Universitario de Cannes | Spidol General Universitario de Alicante|Spidol Universitario Araba|Spidol Royo Vilanova|Spidol Universitario de Burgos|Complejo Hospitalario Universitario de Huelva|Spidol Universitario Reina Sofia de Cordoba|Spidol Universitario Virgen Macarena|Complexo Hospitalario Universitario de Vigo|Clinica Universidar de Navicodra de Navicos | Universitario San Cecilio|Spidol Universitario La Fe|Spidol General Universitario de Valencia|Spidol Universitario Infanta Leonor|Spidol Universitario de Gran Canaria|Spidol General Universitario Santa Lucía|Centro Penitenciario Alicante 1|Spidol Regional Universitario Carlos Haya|Spidol la Virgen General Universitario de Castellón|Spidol Parc Taulí, Sabadell | Chronesch Hepatitis C Infektioun | Dezember 2014 |
|
| NCT03200184 | Teheran University of Medical Sciences | Hepatitis C | September 1, 2016 | Phase 4 |
| NCT03188276 | Drëtt verbonne Spidol, Sun Yat-Sen Universitéit | Chronesch Hepatitis C | 1. Februar 2016 | Fréier Phase 1 |
| NCT01830205 | Bristol-Myers Squibb | Hepatitis C | September 2012 | Phase 1 |
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